David Park, Ph.D.

Professor and Assistant Dean of Research

Dr. David Park

Degrees

Ph.D., Biochemistry, Rutgers University, New Brunswick, NJ, 1994
B.Sc., Cellular and Molecular Biology, University of Michigan, Ann Arbor, MI, 1989

Contact info:

RGN, 451 Smyth Road, Rm. 3510D, Ottawa ON K1H 8M5 Phone: 562-5800 x8816 Email: dpark@uottawa.ca

Research Interests:

Our laboratory is interested in deciphering the mechanisms governing neurodegeneration/injury and development. In terms of the former, we have a substantial effort focussed on Parkinsons disease and stroke. We are principally interested in how PD related genes may affect cell biological function and disease processes. We also have active research on how death related pathways which include calpains and cell cycle activators regulate neuronal activity amd dysfunction. We employ multiple biochemical cellular and animal modelling approaches. The latter include rodent and fly models of degeneration.

Publications:

Andrusiak M, McClellan KA, Dugal-Tessier D, Julian LM, Rodrigues SP, Park DS, Kennedy TE, Slack RS. Rb/E2F regulates expression of neogenin during neuronal migration. Mol Cell Bio 31(2):238-47 (2011)
Germain M, Nguyen AP, Le Grand JN, Arbour N, Vanderluit JL, Park DS, Opferman JT Slack RS. MCL-1 is a stress sensor that regulates autophagy in a developmentally regulated fashion. EMBO J Dec 7th 30(2):395-407 (2010)

Jahani-asl A, Pilon-Larose K, Xu W, Park DS, McBride H, Slack RS. Excitotoxic cell death results in defects in mitochondrial fusion and inner membrane structure which can be rescued by inner membrane GTPase, Opa1. J. Biol. Chem Nov 1 (Epub ahead of print) (2010)
Bouman L, Schlierf A, Lutz AK, Shan J, Deinlein A, Kast J, Galehdar Z, Palmisano V, Patenge N, Berg D, Gasser T, Augustin R, Trümbach D, Irrcher I, Park DS, Wurst W, Kilberg MS, Tatzelt J, Winklhofer KF. Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress. Cell Death Diff. Nov 26th (Epub ahead of print) (2010)

Galedar, Z., Swain, P., Fuerth, B., Callaghan, SM., Townes, TM, Park, DS*, Cregan, S* Neuronal apoptosis induced by ER Stress is regulated by ATF4-CHOP mediated induction of the BH3-only Member PUMA J. Neurosci 30(50):16938-48. (2010)

Huang, E., Qu, Q. Park, D.S. Cdk5: Links to DNA damage, Cell Cycle Aug 9:3142-3 (2010)

Irrcher I, Aleyasin H, Seifert EL, Hewitt SJ, Chhabra S, Phillips M, Lutz AK, Rousseaux MWC, Bevilacqua L, Jahani-Asl A, Callaghan S McLaurin JG, Winklhofer KF, Rizzu P, Rippstein P, Kim RH, Slack RS, Harper M, McBride HM, Mak TW, and Park, DS. Loss of the Parkinson’s Disease-linked gene DJ-1 perturbs mitochondrial dynamics. Hum Mol Genetics 19:3734-46 (2010)

Kanao, T., Venderova, K., Park, DS., Unterman, T., Lu, B., Imai, Y, Activation of FoxO by LRRK2 induces expression of proapoptotic proteins and alters survival of postmitotic dopaminergic neuron in Drosophila Hum Mol Genetics 19:3747-58 (2010)

Huang E., Venderova, K., Haque, E., Zhang, Y., Woulfe, J.M., Slack, RS., Park, DS , The role of Cdk5-mediated apurinic/apyrimidinic endonuclease 1 phosphorylation in neuronal death Nat Cell Bio. 12(6):563-71 (2010)

Biswas, SC#., Zhang, Y#., Iyirhiaro, G., Willet, R., Rodriguez Gonzalez, Y., Cregan, S., Slack, RS., Park, DS*., Greene, LA* Sertad1 plays an essential role in developmental and pathological neuronal death . J. Neurosci 30(11):3973-82 (2010)

Aleyasin H, Rousseaux MWC, Marcogliese PC, Irrcher I, Parsanejad M, Kim RH, Rizzu P, Callaghan SM, Slack RS, Mak TW, Park DS. DJ-1 Protects the Nigrostriatal Axis from the Neurotoxin MPTP by Modulation of the AKT Pathway. Proc Natl Acad Sci USA 107(7):3186-91 (2010)

Zhang, Y., Parsanejad, M., Qu, D., Aleyassin, H., Rodriguez-Gonzalez, Y., Cregan, SP., Slack, RS., Park, DS. Pim-1 Kinase as activator of the cell cycle pathway in neuronal death induced by DNA damage. J. Neurochem, 112(2):497-510 (2010)

Rashidian J, Qu D, Venderova K, Callaghan S, Phillips M, Bland RJ, Slack RS, During MJ, Park DS. Differential roles of nuclear and cytoplasmic Cdk5 and targeting of Prdx2 in ischemic injury models. J. Neurosci, 29(40):12497-505 (2009)

Venderova, K., Kabbach, S., Abdel-Messih, E., Zhang, Y., Patks, R., Imai, Y., Lavoie, M., Slack, RS., Rao, Y., Lu, BW, Haque, E., Park, DS. Interaction of LRRK2 with Parkin, DJ-1 and PINK-1 in a LRRK2 Drosophila model of Parkinson’s disease Hum Mol Gen 18(22):4390-404 (2009)

McCelellan, KA., Vandeluit, JL., Julian, LM., Andrusiak, MG., Dugal-Tessier, D., Park, DS., Slack RS. P107/E2F pathway regulates FGF2 responsiveness in neural precursor cells Mol. Cell Biol., 29(17):4701-13 (2009)

Dagda, RK, Ill, SJC., Kulich, SM., Tandon, A., Park, DS., Chu, CT. Pink1 regulates mitochondrial autophagy through effects on fission in neurons, J. Biol. Chem., 284:13843-55 (2009)

Ruzhynsky VA, Furimsky M, Park DS, Wallace VA, Slack RS. E2F is Required for Early Eye Development. Dev Dyn. 31:238-46 (2009)

Irrcher I., Park, D.S., To live or die by autophagy. Science Signalling 2(65)pe21 (2009)

Vasseur, S., Afzal, S., Tardive-Lacombe, J., Park, DS., Lovanna, JL, Mak TW. DJ-1/Park7 is an important mediator of hypoxia-induced cellular responses. Proc Natl Acad Sci U S A. 106(4):1111-1116 (2009)

Grant, RJ., Sellings, LH., Crocker, SJ., Melloni, E., Park, DS., Clarke, PB., Effects of calpain inhibition on dopaminergic markers and motor function following intrastriatal 6-hydroxydopamine administration in rats. Neuroscience, 158:558-69 (2009)

NArbour, N, Vanderluit, JL, Le Grand, J., Jahani-Asl, A., , Ruzhynsky, V., Cheung E., , Kelly, M., MacKenzie, AE., Park, DS,, Opferman, JT, Slack, RS MCL-1 is a key regulator of apoptosis during CNS development and following DNA damage. J. Neurosci 28(24):6068-78 (2008)

Rodrigues Gonzales Y, Zhang, YBehzadpoor D, Cregan S, Bamforth S, Slack RS, Park DS. CITED2 signals death of cortical neurons after DNA damage. J. Neurosci 28(21):5559-69 (2008)

Iyiriaro, G.O., Brust , TB., Rashidian J., Galehdar Z., Phillips M., Slack, RS., MacVicar, M., Park, DS. Combinatorial Treatment With Flavopiridol And Minocycline Protects Neurons From Global Ischemia. J. Neurochem 105(3):703-13 (2008)

Haque, EM, Callaghan, S., Slack, RS., Fraser, P., Tandon, A., Cookson, M., Park, DS. Role of cytoplasmic Pink1 kinase activity in neuronal survival in MMP+MPTP models of PD in vitro and in vivo. Proc Natl Acad Sci U S A. 105(5):1716-21(2008)

Keramaris E., Ruzhynsky V., Callaghan SM., Wong, E., Davis RJ., Flavell R., Slack, RS., Park, DS. Required roles of BAX and JNKs in central and peripheral nervous system death of retinoblastoma deficient mice. J Biol Chem. 283(1):405-15 (2008)

Aleyasin H,. Rousseaux MWC, Phillips M,. Kim RH, Blandý R, Callaghan S, Slack RS, During M, Mak TW, and Park DS. The Parkinsons disease gene DJ-1 is also a key regulator of stroke induced damage. Proc Natl Acad Sci U S A. 104(47):18748-53 (2007)

Jahani A., Cheung, EC., MacLaurin, JG., Fortin, A., Park, DS., McBride, H., Slack, RS. Dynamic fusion of mitochondrial protects neurons against oxidative damage and excitotoxicity. J. Biol. Chem. 282(33):23788-98, (2007)

Qu, D., Rashidian, J., Mount, MP., Aleyasin, H., Parsanejad, M., Lira, A., Haque, E., Zhang, Y., Callaghan, S., Daigle, M., Rousseaux, MWC., Slack, RS., Albert, PR., Vincent, I., Woulfe, JM., Park, DS. Role of Cdk5 mediated phosphorylation of Prx2 in MPTP toxicity. Neuron 55(1):37-52 (2007)

Qu, D., Zhang, Y., Ma, J., Li, R., Yin, Y., Cao, X., Park, DS The nuclear localization of SET mediated by impalpha3/impbeta attenuates its cytosolic toxicity in neurons. J. Neurochem 103(1):408-22 (2007)

Vanderluit, JL.,Wylie, CA., McClellan, KA.,Ghanem, N., Fortin, A., Callaghan, S., MacLaurin, JG., Park, DS., Slack, RS. The Retinoblastoma family member, p107 regulates the rate of progenitor commitment to a neuronal fate. J.Cell Bio 178(1):129-39 (2007)

Ruzhynsky, V., McClellan, KA., Vanderluit, JL., Furimsky, M., Park, DS Wallace, VA., Slack, RS, Cell cycle regulator E2F4 is a mediator of Shh signaling activity. J. Neurosci 30;27(22):5926-35 (2007)

McClellan, KA., Douda,, DN, Ruzhynsky, VA, Vanderluit, JL., Ferguson, KL., , Chen, D., Bremner, R., Park, DS, Leone G., and Slack RS., Overlapping and unique roles for Rb/E2F1 & 3 in regulating neural precursor proliferation and migration: Evidence for in vivo cell cycle independent functions, Mol. Cell Biol 27(13):4825-43 (2007)

Rashidian , J., Iyirhiaro, GO., and Park, DS, Cell Cycle Machinery and Stroke. Biochim Biophys Acta. 1772(4):484-93 (2007)

Mount, MP., Lira, A., Grimes, DA., Smith P., Faucher S., Slack RS., Anisman H, Hayley, S., and Park, DS, Central nature of interferon-gamma in microglial mediated loss of dopaminergic neurons. J. Neurosci., 27(12):3328-37. (2007)

Lee, J., Kosaras, B., Aleyassin, H., Han, JA. Park, DS., Ratan, R., Kowall, NW., Lee, SW, Hoon, R., Role of cyclooxygenase-2 induction by transcription factor Sp1 and Sp3 in neuronal oxidative and DNA damage response. FASEB J., 20(13):2375-7 (2006)

Cheung, CC., Joza, N., Sennart, NA., McClellan, KA., Neruspiel, M., McMamara, S., MacLaurin, J., Rippstien, P., Park, DS., Shore, GC., McBride, HM., Penninger, JF., Slack, RS. Dissociating the dual roles of AIF in maintaining mitochondrial structure and apoptosis. EMBO 25(17):4061-73 (2006)

Zhang, Y., O’Hare, MJ, Callaghan SM, Slack RS, and Park DS, The Chk1/Cdc25A Pathway as Activators of the Cell Cycle in Neuronal Death Induced by DNA Damage. J. Neurosci, 26(34):8819-28 (2006)

Massa, PT., Aleyasin, H., Park, DS., Mao, X., Barger, SW., NFKappaB in neurons? The uncertainty principle in neurobiology. J, Neurochem 97:607-618. (2006)

Crocker SJ, Hayley SP, Smith PD, Lamba WR, Callaghan SM, Slack RS, Park DS. Stress-Activated MAP Kinase Signaling in Nigral Dopamine Neurons Modifies Axotomy-Induced c-Jun Expressio and Neurodegeneration in vivo. J. Neurochem. 96(2):489-99 (2006)

Smith PD, Mount MP, Shree R, Callaghan S, Slack RS, Anisman H Vincent I, Mao Z and Park DS. A calpain regulated p35/cdk5 complex plays a central role in dopaminergic neuron death in vivo through modulation of the transcription factor MEF2. J. Neurosci., 26(2):440-7 (2006)

Lamba, W., Munoz, DG, Prichett-Pejic, W., Park, DS, and Woulfe, J. MPTP induces intranuclear rodlet formation in mibrain dopaminergic neurons. Brain Res. 1066(1-2):86-91 (2005)

Ni Z, Karaskow E, Yu T, Callaghan S, Der S, Park DS, Xu Z, Pattenden S, Bremner R. Apical Role for BRG1 IN Cytokine-Induced Promoter Assembly. Proc. Natl. Acad Sci., USA (Track II) 102(41):14611-6 (2005)

O’Hare, M.J., Kushwaha, N., Zhang, Y., Aleyassin, H., Callaghan, Slack, RS., Vincent, I., Albert, P., Park, DS. Differential Roles of Nuclear and Cytoplasmic Cdk5 in apoptotic and excitotoxic death. J. Neurosci. 25(39):8954-66 (2005)

Rashidian J, Iyirhiaro G, Aleyasin H, Vincent I, Callaghan S, Slack RS, During M, Park DS. Multiple cyclin-dependent kinases signals are critical mediators of ischemia/excitotoxic neuronal death in vitro and in vivo. Proc. Natl. Acad Sci., USA (Track II) 102(39):14080-5 (2005)

Tang X, Wang X, Gong X, Tong M, Park DS, Xia Z, Mao Z. Cyclin-dependent kinase 5 mediates neurotoxin-induced degradation of the transcription factor myocyte enhancer factor 2. J Neurosci. 25(19):4823-34. (2005)

Cheung CC, Melanson-Drapeau L, Cregan SP, Vanderluit JL, Ferguson KL, McIntosh WC, Park DS, Bennett SAL, Slack RS. AIF is a key factor in Neuronal Cell Death propagated by BAX-Dependent and BAX-Independent Mechanisms. J. Neurosci. 25(6):1324-34. (2005)

Kim RH, Smith PD, Aleyasin H, Hayley S, Pownall S, Wakeman A, You-Ten AJ, Anisman H, *Mak TW, *Park DS. DJ-1 Deficient Mice as a Model for Parkinson’s Disease. Proc. Natl Acad Sci., USA . 102(14):5215-20. (2005)

Keramaris E, Vanderluit JL, Bahadori M, Mousavi K, Davis RJ, Flavell R, Slack RS, Park DS. JNK3 deficiency protects neurons from axotomy induced death in vivo, through mechanisms independent of c-Jun phosphorylation J. Biol. Chem. 280(2):1132-41.(2005)

Last updated: June 13, 2011